Well known for his role in Mad Max 2, as well as The Matrix Revolutions, Spence is a renowned actor. He is currently portraying Zeddicus Zu'l Zorander in Legend of the Seeker. He also appeared as the Mouth of Sauron in Peter Jackson's The Lord of the Rings: The Return of the King. His one scene was cut from the final product, but was included in the Extended Edition DVD. Spence played the role of Tion Medon in Star Wars Episode III: Revenge of the Sith and provided the voice of Chum in Finding Nemo. He played as Lord Rhoop in The Chronicles of Narnia: Voyage of the Dawn Treader, which was released in December 2010.